ENERGY SUBSTRATE IS KEY

In the resting state,  BRAIN, HEART, LIVER, and KIDNEYS  consume  the majority of available energy.

CONTRIBUTION OF DIFFERENT ORGANS AND TISSUES TO ENERGY EXPENDITURE
WEIGHTMETABOLIC RATE
ORGAN OR TISSUEkg% OF TOTALKcal/kg tissue/D% OF TOTAL
Kidneys0.30.54408.0
Brain1.42.024020.0
Liver1.82.620021.0
Heart0.30.54409.0
Muscle2840.01322.0
Adipose tissue1521.444.0
Other (e.g., skin, gut, bone)23.233.01216.0
Total70100100
Data for a 70-kg (154 lb) man from Elia M Organ and tissue contribution to metabolic rate
In: Kinney JM, Tucker HN, eds. Energy Metabolism: Determinants and Cellular Corollaries New York: Raven Press, 1992:61-79.
Adapted from Matthews DE. Proteins and Amino Acids. In: Shils ME, Shike M, Ross AC, Caballero B, and Cousins RJ, eds. Modern Nuitrition in Health and Disease, 10th ed. Baltimore: Lippincott Williams and Wilkins, 2006: 1018
See: Berg JM, Tymoczko JL, and Stryer L. Biochemistry, 5th ed. New York: WH Freeman, 2002, Section 30.2 “EACH ORGAN HAS A UNIQUE METABOLIC PROFILE: FATTY ACIDS ARE THE HEART’S MAIN SOURCE OF FUEL; ALPHA KETO-ACIDS DERIVED FROM THE DEGRADATION OF AMINO ACIDS ARE THE LIVER’S OWN FUEL”; See: Seldin and Giebisech The Kidney: Physiology and Pathophysiology 1-2.  On the basis of their relative concentration in the kidney, fatty acids and ketone bodies compete as fuels for the kidney, which metabolizes glucose poorly. An efficient metabolic diet must factor in fat and protein substrate as optimal fuel for heart, liver, and kidney. The synergies of balanced, pre-formed fatty acids, nutrition, and regulation of caloric intake, support efficient energy production.

  • Epilepsy
  • Autism
  • Learning Disabilities
  • Attention Deficit Hyperactive Disorder
  • Parkinson’s Disease
  • Amyotrophic Lateral Sclerosis
  • Auto-Immune Diseases
  • Allergies
  • Alzheimer’s Disease
  • Diabetes (types 1 & 2)
  • Weight Control
  • Celiac Disease
  • Irritable Bowel and Leaky Gut
  • Brain Cancer
  • Coronary Disease
  • Trauma

All of the above are cited in the current medical literature as potentially benefitting from KD. ASEK diet conforms to the basic formulation of  medically prescribed KD: high fat, adequate protein, low carbohydrate, and avoidance of excessive caloric and fluid intake. Ketone bodies per se, however, have not been proven to account for KD therapeutic effect. ASEK Diet is  formulated  to curb abnormally high levels of ketone bodies in blood and urine. ASEK protocol provides guidelines to achieve normal  ketone levels in blood  (euketonemia), acid-base (pH) balance, and comprehensive nutritional support. Adverse effects of hyperketonemia  (abnormally high level of ketone bodies in the blood) and ketonuria (abnormally high level of ketone bodies in the urine) are thus prevented.

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